Operational Success Engineer for Manufacturing & Critical Applications

Company: Eli Lilly and Company
Location: Indianapolis
Posted on: February 15, 2026

Job Description:

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. The Cloud and Connectivity organization is seeking an Operational Success Engineer to partner with teams supporting manufacturing and other critical business applications . In this role, you will be accountable for ensuring the reliability, resilience, and operational success of IT infrastructure that underpins applications where downtime, instability, or performance degradation can have significant operational or business impact. As an Operational Success Engineer, your mission is to ensure the IT infrastructure aspects of critical applications are successfully implemented, operated, and evolved on reliable infrastructure across network, compute, storage, virtualization, and cloud?connected platforms. This role focuses on proactive risk prevention, technical coordination, and incident leadership , rather than reactive support or commercial account management. What You’ll Be Doing You will serve as the technical success owner for infrastructure supporting manufacturing and other critical applications, ensuring platforms meet availability, resiliency, performance, and security expectations. Working within the IT Infrastructure organization, you will: Act as the primary technical partner for application and site stakeholders, providing guidance on infrastructure architecture, configuration, and operational readiness. Proactively assess and manage infrastructure health across network, compute, storage, virtualization, and cloud?connected services supporting critical applications. Partner closely with application owners, plant and business stakeholders, engineering, cybersecurity, and global infrastructure teams to align infrastructure capabilities with application requirements and uptime expectations. Serve as the technical coordination point for infrastructure engagement, ensuring application needs are clearly represented and addressed by the appropriate specialist teams. Lead proactive health and reliability reviews , focusing on dependency mapping, trend analysis, lifecycle risks, and capacity constraints. Coordinate incident response and technical escalations for application?impacting issues, ensuring rapid engagement, clear communication, and efficient recovery. Drive root cause analysis and corrective/preventative actions , working with engineering and service partners to reduce recurrence and improve long?term stability. Promote standard architecture, repeatable patterns, and improved observability to increase consistency, resilience, and predictability across critical applications. Support technology roadmaps and lifecycle planning , guiding modernization efforts and preparing applications for future demands. Provide technical direction and oversight to internal SMEs and service providers , ensuring day?to?day operations align with reliability and availability objectives. How You’ll Succeed Be Bold: Advocate for the reliability and stability of manufacturing and other critical applications. Elevate risks early, challenge fragile or legacy designs, and influence teams to prioritize improvements that protect application availability. Be Fast: Lead rapid technical coordination during incidents impacting critical applications. Ensure the right teams are engaged quickly to minimize disruption and accelerate recovery. Be Proactive: Anticipate risks through regular health reviews, trend analysis, and close partnership with stakeholders. Drive preventative improvements before issues affect operations. Be Your Best: Maintain deep understanding of how infrastructure enables critical applications. Continuously improve reliability through standardization, observability, and disciplined execution while building trust through consistent delivery. What You Should Bring Strong technical foundation supporting enterprise or mission?critical applications , with experience in one or more of network, compute, storage, virtualization, and cloud?connected platforms. Proven ability to lead technical coordination across multiple applications or sites , driving consistent reliability and uptime outcomes. Experience supporting manufacturing systems and other critical applications where availability and performance are essential. Demonstrated strength in incident leadership and escalation management , including root cause analysis and follow?through on preventative actions. Familiarity with monitoring, observability, and reliability practices , such as health dashboards, trend analysis, and capacity planning. Excellent analytical, problem?solving, and communication skills, with the ability to explain technical risks and recommendations to both technical and non?technical stakeholders. A track record of influencing outcomes across global, cross?functional organizations without direct authority. Basic Requirements Bachelor’s degree in Computer Science, Information Technology, Engineering, or a related technical field with 5 years of experience in IT infrastructure, technical support, service delivery, customer or operational success engineering, or similar roles supporting critical applications. Experience coordinating large?scale, multi?application or multi?site initiatives focused on reliability and operational continuity. Experience driving execution across global teams. Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1. ? Additional Information Hybrid role located in Indianapolis, IN (relocation required) Organization Overview Lilly IT builds and maintains capabilities using cutting edge technologies like most prominent tech companies. What differentiates Lilly IT is that we redefine what’s possible through tech to advance our purpose – creating medicines that make life better for people around the world, like data driven drug discovery and connected clinical trials. We hire the best technology professionals from a variety of backgrounds, so they can bring an assortment of knowledge, skills, and diverse thinking to deliver innovative solutions in every area of our business. The Global Information and Services Tech team is at the forefront of digitalization to enable and advance the entire company, with increased productivity and best-in-class Customer experiences. This team provides a robust and sustainable infrastructure of hardware, software and services that are critical to enable our global workforce and business to operate and transform. As leaders in technology and understanding business requirements and challenges, this team defines and leads the overall company technology strategy. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups. Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $64,500 - $151,800 Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees. WeAreLilly

Keywords: Eli Lilly and Company, Greenwood , Operational Success Engineer for Manufacturing & Critical Applications, IT / Software / Systems , Indianapolis, Indiana