Advisor - Process Translation and Execution Chemist Lilly Medicine Foundry

Company: Eli Lilly and Company
Location: Indianapolis
Posted on: June 27, 2025

Job Description:

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. Organization and Position Overview Lilly recently announced a $4.5 billion investment to create the Lilly Medicine Foundry, a new center for advanced manufacturing and drug development. The first-ever facility of its kind, combining research and manufacturing in a single location, the Medicine Foundry will allow Lilly to further develop innovative solutions to optimize manufacturing processes and increase capacity for clinical trial medicines, while also reducing costs and environmental impact. Responsibilities: In this role, the Chemist would be responsible for transfer of chemical processes from development labs to the pilot plant to enable translation to cGMP production of kilogram quantities of API to supply clinical trials. The Chemist would be actively involved in receiving chemistry from early phase process chemistry and medicinal chemistry labs: evaluating the safety of the incoming procedures in collaboration with the safety group and process engineering, ordering and staging chemicals, authoring batch records, obtaining reference materials and participating in setting up analytical methods, performing familiarization reactions to ensure plant readiness of process steps including chemical reactions, distillations, extractions, and crystallization /isolations at the Medicines Foundry. Performing and documenting Definitive Lab Trials of processes to confirm plant readiness and use-test key raw materials. Training and assisting less experienced scientists in the Process Translation and Execution labs. Participation in the development, supervision and mentoring of other chemists, possibly technicians. Basic Requirements BS, MS or PhD in Chemistry 15 years’ experience developing and scaling reactions from gram to hundreds of grams scale. 10 years of experience with small molecule processing in a cGMP environment. Additional Skills and Preferences Supervisory experience, ideally of small teams Expected to maintain a safe, clean, well-organized, and productive chemistry lab. Good working knowledge of organic chemistry and mechanisms and application to reaction improvement and optimization. Experience with a variety of analytical techniques: HPLC/UPLC, MS, NMR, GC, KF, DSC, XRD, etc. Understanding of implications of scale-up on chemical processes and the impact on process efficiency, safety and quality. Process quantification and tying up mass balance for products and by-products. Experience tracking and quantifying fate and purge of impurities throughout multi-step chemical processes. Familiarity with physical/solid state chemistry: crystallization development and optimization, understanding of polymorphism and particle size control, and safe handling of solids/dry end processing. Proficiency with the purification of chemicals via chromatography and distillation. Maintaining a well-organized and detailed lab notebook with accurate descriptions of the chemistry and observations to enable the preparation of technical packages/technical transfers and accurate replication in receiving labs. Participate in training, mentoring, and supporting chemists in safe and practical process chemistry techniques during demonstrations and material preparations. Ability to work cross-functionally across teams and levels with engineers, analytical chemists, plant operators, safety and quality representatives. Other Information: Initial location at Lilly Technology Center, Indianapolis. Permanent location at the new Lilly Medicines Foundry in Lebanon, Indiana. Limited domestic and international travel ( Role requires ability to work in manufacturing and laboratory environments. Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( https://careers.lilly.com/us/en/workplace-accommodation ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups. Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $121,500 - $198,000 Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees. WeAreLilly

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